Tumor suppressor protein 53 (p53) plays a central role in the control of genome stability, acting primarily through the transcriptional activation of stress‐response genes. However, many p53 binding sites are located at genomic locations with no obvious regulatory‐link to known stress‐response genes. We recently discovered p53 binding sites within retrotransposon‐derived elements in human and mouse subtelomeres. These retrotransposon‐derived p53 binding sites protected chromosome ends through transcription activation of telomere repeat RNA, as well as through the direct modification of local chromatin (...) structure in response to DNA damage. Based on these findings, I hypothesize that a class of p53 binding sites, including the retrotransposon‐derived p53‐sites found in subtlomeres, provide a primary function in genome stability by mounting a direct and local protective chromatin‐response to DNA damage. I speculate that retrotransposon‐derived p53 binding sites share features with telomere‐repeats through an evolutionary drive to monitor and maintain genome integrity. (shrink)

The ancient problem of the relationship of the continuous to the discrete, since its discovery by the Greeks, has posed a range of immensely fruitful challenges to both philosophical and mathematical thought, leading to a variety of mathematical and conceptual innovations whose positive development actively continues today. In this brief section introduction, I selectively outline some significant moments at which this problem has provided important historical occasions for concrete mathematical innovation as well as closely linked philosophical insights, before introducing the (...) particular contributions of the section authors to historical and contemporary research and practice into the nature and structure of the continuum, the construction of real numbers, the foundations of analysis, and the logical, set-theoretical, and computational underpinnings of the structure of continuously valued numbers in the most general sense, in both constructive and nonconstructivist contexts. (shrink)

In this book, Livingston develops the political implications of formal results obtained over the course of the twentieth century in set theory, metalogic, and computational theory. He argues that the results achieved by thinkers such as Cantor, Russell, Godel, Turing, and Cohen, even when they suggest inherent paradoxes and limitations to the structuring capacities of language or symbolic thought, have far-reaching implications for understanding the nature of political communities and their development and transformation. Alain Badiou's analysis of logical-mathematical structures forms (...) the backbone of his comprehensive and provocative theory of ontology, politics, and the possibilities of radical change. Through interpretive readings of Badiou's work as well as the texts of Giorgio Agamben, Jacques Lacan, Jacques Derrida, Gilles Deleuze, and Ludwig Wittgenstein, Livingston develops a formally based taxonomy of critical positions on the nature and structure of political communities. These readings, along with readings of Parmenides and Plato, show how the formal results can transfigure two interrelated and ancient problems of the One and the Many: the problem of the relationship of a Form or Idea to the many of its participants, and the problem of the relationship of a social whole to its many constituents. (shrink)

Paul M. Pietroski presents an ambitious new account of human languages as generative procedures that respect substantive constraints. He argues that meanings are neither concepts nor extensions, and sentences do not have truth conditions; meanings are composable instructions for how to access and assemble concepts of a special sort.

In the Logic of Being: Realism, Truth, and Time, the influential philosopher Paul M. Livingston explores and illuminates truth, time, and their relationship by employing methods from both Continental and analytic philosophy.

_Philosophy and the Vision of Language_ explores the history and enduring significance of the twentieth-century turn to language as a specific object of investigation and resource for philosophical reflection. It traces the implications of the access to language in some of the most prominent projects and results of the historical and contemporary tradition of analytic philosophy, including the projects of Frege, Wittgenstein, Sellars, Quine, Brandom, and Cavell. Additionally, it demonstrates the deep and enduring connections between the analytic tradition’s inquiry into (...) language and the parallel inquiries of phenomenology, critical theory, and deconstruction over the course of the twentieth century. Finally, it documents some of the enduring consequences of philosophy’s inquiry into language for contemporary questions of social and political life. The book provides a clear, accessible and widely inclusive introduction to the relevance of language for analytic and continental philosophy in the twentieth century and is readable by non-specialist audiences. It should contribute to a growing historical sense of the location of the analytic tradition in a broader geography of social, political and critical thought. Furthermore, it contributes to building bridges between this tradition and the neighboring continental ones from which it has all too often been estranged. (shrink)

Paul M. Pietroski, University of Maryland I had heard it said that Chomsky’s conception of language is at odds with the truth-conditional program in semantics. Some of my friends said it so often that the point—or at least a point—finally sunk in.

The Mind-Body Problem Questions: What is the mind? What is its connection to the body? Most basic division of answers: Dualist and Materialist (or Physicalist) responses.

The present essay is addressed simultaneously to two distinct audiences.

Investigation and analysis of the history of the concepts employed in contemporary philosophy of mind could significantly change the contemporary debate about the explainability of consciousness. Philosophical investigation of the history of the concept of qualia and the concept of scientific explanation most often presupposed in contemporary discussions of consciousness reveals the origin of both concepts in some of the most interesting philosophical debates of the twentieth century. In particular, a historical investigation of the inheritance of concepts of the elements (...) of experience and the nature of scientific explanation from C. I. Lewis and Rudolf Carnap to contemporary theorists like David Chalmers shows the profound continuity of these concepts throughout the analytic tradition, despite important changes in the dimensions of philosophical relevance and significance that have characterized the emerging debate. I argue that, despite the significant methodological shift from the foundationalist epistemology of the 1920s to today's functionalist explanations of the mind, the problem of explaining consciousness has remained the problem of analysing or describing the logical and relational structure of immediate, given experience. Appreciation of this historical continuity of form recommends a more explicit discussion of the philosophical reasons for the underlying distinction between structure and content, reasons that trace to Lewis and Carnap's influential but seldom-discussed understanding of the relationship between subjectivity, conceived as the realm of private, ineffable contents, and objectivity, understood as public, linguistic expressibility. With this historical background in mind, the contemporary debate about the explanation of consciousness can be re-interpreted as a debate about the relationship between ineffable experience and structurally conceived meaning. (shrink)

One difference between Russell’s logical atomism in The Philosophy of Logical Atomism and Wittgenstein’s in the Tractatus is that Russell’s doctrine is explicitly epistemological, whereas Wittgenstein’s is not; another difference is that Wittgenstein gives an a priori argument for the doctrine of logical atomism whereas Russell gives no such argument. I argue that these two differences are instructively connected: Russell’s focus on epistemology prevents him from being able to give a motivated argument for the truth of logical atomism. Furthermore, I (...) argue that this is not just a contingent failure of Russell’s system: no primarily epistemological atomism can avail itself of Wittgenstein’s style of a priori argument for the truth of atomism. An important suggestion of the argument, illuminating with respect to the subsequent history of analytic philosophy, is that Russell’s logical atomism already contains the seeds of verificationism in a nascent form, whereas Wittgenstein’s atomism has no tendency toward verification. (shrink)

A study in the philosophy of science, proposing a strong form of the doctrine of scientific realism' and developing its implications for issues in the philosophy of mind.

A Neurocomputationial Perspective illustrates the fertility of the concepts and data drawn from the study of the brain and of artificial networks that model the...

Paul Pietroski presents an original philosophical theory of actions and their mental causes. We often act for reasons: we deliberate and choose among options, based on our beliefs and desires. However, bodily motions always have biochemical causes, so it can seem that thinking and acting are biochemical processes. Pietroski argues that thoughts and deeds are in fact distinct from, though dependent on, underlying biochemical processes within persons.

A study of how syntax relates to meaning by a leader of the new generation of philosopher-linguists.

Eliminative materialism is the thesis that our common-sense conception of psychological phenomena constitutes a radically false theory, a theory so fundamentally defective that both the principles and the ontology of that theory will eventually be displaced, rather than smoothly reduced, by completed neuroscience. Our mutual understanding and even our introspection may then be reconstituted within the conceptual framework of completed neuroscience, a theory we may expect to be more powerful by far than the common-sense psychology it displaces, and more substantially (...) integrated within physical science generally. My purpose in this paper is to explore these projections, especially as they bear on (1) the principal elements of common-sense psychology: the propositional attitudes (beliefs, desires, etc.), and (2) the conception of rationality in which these elements figure. (shrink)

In _Matter and Consciousness_, Paul Churchland presents a concise and contemporary overview of the philosophical issues surrounding the mind and explains the main theories and philosophical positions that have been proposed to solve them. Making the case for the relevance of theoretical and experimental results in neuroscience, cognitive science, and artificial intelligence for the philosophy of mind, Churchland reviews current developments in the cognitive sciences and offers a clear and accessible account of the connections to philosophy of mind. For (...) this third edition, the text has been updated and revised throughout. The changes range from references to the iPhone's "Siri" to expanded discussions of the work of such contemporary philosophers as David Chalmers, John Searle, and Thomas Nagel. Churchland describes new research in evolution, genetics, and visual neuroscience, among other areas, arguing that the philosophical significance of these new findings lies in the support they tend to give to the reductive and eliminative versions of materialism. Matter and Consciousness, written by the most distinguished theorist and commentator in the field, offers an authoritative summary and sourcebook for issues in philosophy of mind. It is suitable for use as an introductory undergraduate text. (shrink)

An updated version of Plato's Dialogues, this adaptation takes place in contemporary times and is set at Reed College in Portland, Oregon. Through the characters' central discussions of Creationist and Materialist theories of evolution, together with their moral and social implications and ramifications, the author defines philosophy and science. This fresh approach to complex philosophical subjects will be an interesting supplement to courses in philosophy.

For the uninitiated, there are two major tendencies in the modeling of human cognition. The older, tradtional school believes, in essence, that full human cognition can be modeled by dividing the world up into distinct entities -- called __symbol s__-- such as “dog”, “cat”, “run”, “bite”, “happy”, “tumbleweed”, and so on, and then manipulating this vast set of symbols by a very complex and very subtle set of rules. The opposing school claims that this system, while it might be good (...) at concluding that Paris is the capital of France or that there must be blood flowing in the left-rear leg of a cow, can never capture the full measure -- indeed, the essence -- of human cognition. For them, the essential features of cognition emerge from the combined effects of myriad, tiny actions far below the surface of consciousness. This is the camp to which Paul Churchland belongs. (shrink)

This paper expounds that besides the well-known spatio-temporal problem there is a causal problem of entanglement: even when one neglects spatio-temporal constraints, the peculiar statistics of EPR/B experiment is inconsistent with usual principles of causal explanation as stated by the theory of causal Bayes nets. The conflict amounts to a dilemma that either there are uncaused correlations or there are caused independences . I argue that the central ideas of causal explanations can be saved if one accepts the latter horn (...) and explains the unfaithful independences by a stable fine-tuning of the causal parameters. (shrink)

Theories of content purport to explain, among other things, in virtue of what beliefs have the truth conditions they do have. The desire for such a theory has many sources, but prominent among them are two puzzling facts that are notoriously difficult to explain: beliefs can be false, and there are normative constraints on the formation of beliefs.2 If we knew in virtue of what beliefs had truth conditions, we would be better positioned to explain how it is possible for (...) an agent to believe that which is not the case. Moreover, we do not say merely of such an agent that he believes that p when p is not the case. We say the agent made a mistake, and often criticize him accordingly; we think agents ought not have false beliefs, and that such beliefs should be changed; etc. An adequate theory of content would, presumably, reveal the source of these normative facts about the mental lives of agents. Indeed, it is typically taken to be an adequacy constraint on a theory of content that it help explain the possibility of error and the "normativity" of content. Teleological theories of content promise to do just this. (shrink)

To understand the consequences of cleansing, Lee and Schwarz favor a grounded procedures perspective over recently developed disgust theory. We believe that this position stems from three errors: (1) interpreting cleansing effects as broader than they are; (2) not detailing the proximate mechanisms underlying disgust; and (3) not detailing adaptive function versus system byproducts when developing the grounded procedures perspective.

Fitouchi et al. persuasively argue against popular disgust-based accounts of puritanical morality. However, they do not consider alternative account of moral condemnation that is also based on the psychology of disgust. We argue that these other disgust-based accounts are more promising than those dismissed in the target article.

The problem of explaining consciousness remains a problem about the meaning of language: the ordinary language of consciousness in which we define and express our sensations, thoughts, dreams and memories. This book argues that the problem arises from a quest that has taken shape over the twentieth century, and that the analysis of history provides new resources for understanding and resolving it. Paul Livingston traces the development of the characteristic practices of analytic philosophy to problems about the relationship of (...) experience to linguistic meaning, focusing on the theories of such philosophers as Carnap, Schlick, Neurath, Husserl, Ryle, Putnam, Fodor and Wittgenstein. Clearly written and avoiding technicalities, this book will be eagerly sought out by professionals and graduate students in philosophy and cognitive science. (shrink)

I argue that linguistic meanings are instructions to build monadic concepts that lie between lexicalizable concepts and truth-evaluable judgments. In acquiring words, humans use concepts of various adicities to introduce concepts that can be fetched and systematically combined via certain conjunctive operations, which require monadic inputs. These concepts do not have Tarskian satisfaction conditions. But they provide bases for refinements and elaborations that can yield truth-evaluable judgments. Constructing mental sentences that are true or false requires cognitive work, not just an (...) exercise of basic linguistic capacities. (shrink)

In _ Plato's Camera_, eminent philosopher Paul Churchland offers a novel account of how the brain constructs a representation -- or "takes a picture" -- of the universe's timeless categorical and dynamical structure. This construction process, which begins at birth, yields the enduring background conceptual framework with which we will interpret our sensory experience for the rest of our lives. But, as even Plato knew, to make singular perceptual judgments requires that we possess an antecedent framework of abstract categories (...) to which any perceived particular can be relevantly assimilated. How that background framework is assembled in the first place is the motivating mystery, and the primary target, of Churchland's book. Unexpectedly, this neurobiologically grounded account of human cognition also provides a systematic story of how such low-level epistemological activities are integrated within an enveloping framework of linguistic structures and regulatory mechanisms at the social level. As Churchland illustrates, this integration of cognitive mechanisms at several levels has launched the human race on an epistemological adventure denied to all other terrestrial creatures. (shrink)

Paul M. Pietroski, University of Maryland For any sentence of a natural language, we can ask the following questions: what is its meaning; what is its syntactic structure; and how is its meaning related to its syntactic structure? Attending to these questions, as they apply to sentences that provide evidence for Davidsonian event analyses, suggests that we reconsider some traditional views about how the syntax of a natural sentence is related to its meaning.

The emerging field of quantum mereology considers part-whole relations in quantum systems. Entangled quantum systems pose a peculiar problem in the field, since their total states are not reducible to that of their parts. While there exist several established proposals for modelling entangled systems, like monistic holism or relational holism, there is considerable unclarity, which further positions are available. Using the lambda operator and plural logic as formal tools, we review and develop conceivable models and evaluate their consistency and distinctness. (...) The main result is an exhaustive taxonomy of six distinct and precise models that both provide information about the mereological features as well as about the entangled property. The taxonomy is well-suited to serve as the basis for future systematic investigations. (shrink)

The doctrine that the character of our perceptual knowledge is plastic, and can vary substantially with the theories embraced by the perceiver, has been criticized in a recent paper by Fodor. His arguments are based on certain experimental facts and theoretical approaches in cognitive psychology. My aim in this paper is threefold: to show that Fodor's views on the impenetrability of perceptual processing do not secure a theory-neutral foundation for knowledge; to show that his views on impenetrability are almost certainly (...) false; and to provide some additional arguments for, and illustrations of, the theoretical character of all observation judgments. (shrink)

We examine possible causal structures of experiments with entangled quantum objects. Previously, these structures have been obscured by assuming a misleading probabilistic analysis of quantum non locality as 'Outcome Dependence or Parameter Dependence' and by directly associating these correlations with influences. Here we try to overcome these shortcomings: we proceed from a recent stronger Bell argument, which provides an appropriate probabilistic description, and apply the rigorous methods of causal graph theory. Against the standard view that there is only an influence (...) between the measurement outcomes, we show that there must be an influence from one setting to its distant outcome: EPR correlations can only come about if one of the outcomes is a common effect of both settings. Our discussion makes explicit under which assumptions similar conclusions from information theoretic considerations can be interpreted causally. (shrink)

"Churchland and Hooker have collected ten papers by prominent philosophers of science which challenge van Fraassen's thesis from a variety of realist perspectives. Together with van Fraassen's extensive reply... these articles provide a comprehensive picture of the current debate in philosophy of science between realists and anti-realists."—Jeffrey Bub and David MacCallum, Foundations of Physics Letters.

The philosophical problem of mental causation concerns a clash between commonsense and scientific views about the causation of human behaviour. On the one hand, commonsense suggests that our actions are caused by our mental states—our thoughts, intentions, beliefs and so on. On the other hand, neuroscience assumes that all bodily movements are caused by neurochemical events. It is implausible to suppose that our actions are causally overdetermined in the same way that the ringing of a bell may be overdetermined by (...) two hammers striking it at the same time. So how are we to reconcile these two views about the causal origins of human behaviour? One philosophical doctrine effects a nice reconciliation. Neuralism, or the token-identity theory, states that every particular mental event is a neurophysiological event and that every action is a physically specifiable bodily movement. If these identities hold, there is no problem of causal overdetermination: the apparently different causal pathways to the behaviour are actually one and the same pathway viewed from different perspectives. This attractively simple view is enjoying a recent revival in fortunes. (shrink)